A diabetic foot ulcer acts as a portal for systemic infections such as cellulitis, infected foot ulcers, and osteomyelitis. These are especially dangerous to patients with diabetes, whose impaired immunity increases their risk for local and systemic infection. Therefore, debridement and antibiotic therapy should be initiated as soon as possible. Blood sugar should also be monitored closely and controlled, because hyperglycemia may increase the virulence of infectious microorganisms. 

• • Optimal glucose control.
  • Debridement – removal of all hyperkeratotic (thickened) skin, infected and nonviable, including necrotic (dead), tissue, slough, foreign debris, and residual material from dressings.
  • Systemic antibiotics for deep infection, drainage, and cellulitis.
  • Off-loading – Relieving the pressure from the ulcerated areas by having the patient wear special foot gear, a brace, specialized castings, or using a wheelchair or crutches.
  • Creating a moist wound environment.
  • Treatment with growth factors and/or cellular therapy if the wound is not healing.